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Sildenafil dosage and administration. The doses listed above are intended to be the minimum effective dosages as determined in clinical studies. The total daily dosage of sildenafil can also be modified depending on personal preferences, body weight and metabolism.
It has been suggested that high-dose oral administration of sildenafil may induce a significant degree of metabolic acidosis, which could increase the
Is generic cialis approved in canada risk of a serious adverse event. The possibility of metabolic acidosis should therefore be carefully considered when prescribing and administering sildenafil pills. High-dose oral administration should also be avoided by patients with renal insufficiency or hypovolemic conditions.
It was also shown in a phase I, randomized, double-blind, placebo-controlled clinical trial that sildenafil tablets were safe at the dose of 5 mg/day for 10 days in older men with erectile dysfunction (ED) [see Drug Interactions (7)].
It should be noted that sildenafil is not available as a non-prescribed drug in any country. addition, a maximum dose of sildenafil 10,000 U/day has been set for safety reasons.
The potential risk for side effects should be kept in mind when considering the use of this medication. following warnings should be considered when prescribing, dispensing, and/or using this medicine:
Serious adverse events (AEs) such as stroke, hypotension, pulmonary embolism, and cardiovascular collapse have been reported in patients using propranolol-containing preparations.
Serious heart rhythm abnormalities including QT prolongation, Torsades de Pointes, and V-P wave abnormalities have been seen in patients receiving sildenafil.
Liver enzymes such as alanine aminotransferase, aspartate aminotransferase and gamma-glutamyltransferase have been seen to increase in patients following dose increases.
These findings have been observed in a dose-related manner.
In clinical trials with sildenafil, hepatotoxicity, especially high doses of sildenafil, including fatal cases have been observed. There a few reports of increased hepatic enzyme levels [see Warnings and Precautions (5.4) Clinical Pharmacology (12.2); Drug Interactions (7)]. There have also been a few reports of syndrome called "sildenafil hepatotoxicity" with concomitant use of amiodarone, quinidine, or amiodarone/quinidine.
There have been reports of hypersensitivity reaction including rash, angioedema, and anaphylactic shock in patients with preexisting severe, long-standing, abnormal liver function. This type of reaction has also been reported in patients taking other NSAIDs like piroxicam.
The most common adverse reactions reported in clinical trials related to sildenafil use include rash, erectile dysfunction, and drowsiness.
Adverse reactions reported in postmarketing reports with sildenafil include constipation, anorgasmia, nausea, vomiting, anxiety, dizziness, headache, fatigue, and somnolence. Increased bodyweight is reported as a result of sildenafil treatment. Hyperglycemia 3.0 mg/dL has also been reported after oral administration of sildenafil at higher doses. Patients are encouraged to monitor their blood sugar levels at regular intervals.
The use of sildenafil has been associated with increased risk of serious cardiomyopathy.
The most common adverse reactions reported in postmarketing reports related to PDE-5 inhibitors include dyspnea, asthenia, dizziness, headache, and gastrointestinal symptoms.
Sildenafil may also cause the following serious side effects when used concomitantly with other anabolic steroids, and/or when coadministered with antihypertensive agents:
Clinical studies of sildenafil in combination with other anabolic steroids and/or antihypertensive agents have demonstrated an increased risk of serious cardiovascular events (1.9-6.5). include sildenafil oral dose angina, myocardial infarction, and cardiovascular collapse, particularly in patients with existing cardiovascular disease. There is an increased risk for serious cardiovascular events with concomitant use of sildenafil and sildenafil/naproxen. In addition, concomitant use of sildenafil and tadalafil may result in the development of a serious skin reaction.
Some patients have experienced an increase in plasma levels of theophylline and other nootropics. Although no causal relationship has been established with regard to sildenafil, theophylline may increase the risk of serious skin irritation. However, it is recommended that theophy.
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