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A second group of patients (the only ones who did not have a prior history of venous thromboembolic disease) were started on a combined oral valacyclovir + cidofovir (3,500mg every 8 weeks) in addition to valacyclovir + diclofenac (1,600mg every 9 weeks).
In all three patients, venosebaceous reactions were mild with minimal or no impairment of activities daily living.
The risk associated with valacyclovir + diclofenac among patients with a previous history of venous thromboembolic disease is "potentially very high", says Bose.
"Valacyclovir can reduce venous thrombi in patients who are taking valacyclovir (or other CTCVs), but it is unclear whether can reduce or modify this effect in patients without a prior history of thromboembolic disease or who are using other CTCVs without a prior history of venous thromboembolic disease."
"Some studies suggest that these findings could reflect a decreased number of thrombi in individuals with prior thromboembolic disease, due to the reduction in anti-thrombotic therapy treatment requirements and in an effect to attenuate the incidence of venous thromboembolic reactions," says Bose.
It is unknown if this might be observed in all patients who have an effect in this way; however, if so, it could have serious implications for the patient.
"In patients with prior thromboembolic disease, an early antiplatelet response to anti-thrombotic drugs is likely affect venous thromboembolism and/or thromboembolic anemia, thus exacerbating complications in patients taking CTCVs," says Bose.
"In addition, an early CTCV can cause thromboembolic reactions by increasing thrombi in and around the spleen."
As such, the use of CTCVs can trigger a clinical complication called thrombosis or embolism (thrombosis is a blood clot within
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This could potentially occur if CTCVs are combined with an anti-thrombotic drug (for example, when a patient is being treated with a blood thinner, for example, warfarin), or if CTCVs are combined with valacyclovir, says Bose.
"These findings suggest that in patients without
doxycycline for rosacea uk a prior history of thromboembolic disease, the use CTCVs may result in increased thrombosis. addition, these findings suggest that the risk associated
Esomeprazole brands australia with these agents of triggering a thrombosis in patients with prior thromboembolic disease is possibly very high."
For patients already taking anti-thrombotic drugs, these findings could have serious implications for the benefit they expect to derive, says Bose.
In individuals with a past history of ven.
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